| 7,79 % | Armistice Capital LLC | 4.236.000 | 58.000 | 31/12/2023 |
| 7,08 % | EcoR1 Capital, LLC | 3.851.507 | 0 | 31/12/2023 |
| 4,65 % | The Vanguard Group, Inc. | 2.529.668 | 47.711 | 31/12/2023 |
| 4,08 % | BlackRock Institutional Trust Company, N.A. | 2.221.266 | 144.958 | 31/12/2023 |
| 2,38 % | Farallon Capital Management, L.L.C. | 1.292.000 | 0 | 31/12/2023 |
| 15,77 % | Neurocrine Biosciences Inc | 8.575.316 | 4.395.588 | 23/2/2023 |
| 1,79 % | T. Rowe Price Associates, Inc. | 976.285 | -169.771 | 31/12/2023 |
| 1,71 % | Dimensional Fund Advisors, L.P. | 932.231 | 153.291 | 31/12/2023 |
| 1,25 % | Geode Capital Management, L.L.C. | 678.878 | 31.933 | 31/12/2023 |
| 1,18 % | AQR Capital Management, LLC | 639.287 | 440.465 | 31/12/2023 |
| 1,14 % | State Street Global Advisors (US) | 619.812 | 37.583 | 31/12/2023 |
| 1,01 % | Federated MDTA LLC | 551.576 | -32.309 | 31/12/2023 |
| 0,86 % | American Century Investment Management, Inc. | 470.229 | 157.324 | 31/12/2023 |
| 0,77 % | Acadian Asset Management LLC | 417.821 | -212.342 | 31/12/2023 |
| 0,75 % | D. E. Shaw & Co., L.P. | 406.044 | -220.079 | 31/12/2023 |
| 0,61 % | GlobeFlex Capital, L.P. | 331.290 | -122.305 | 31/12/2023 |
| 0,56 % | Ikarian Capital LLC | 305.857 | 0 | 31/12/2023 |
| 0,55 % | BlackRock Financial Management, Inc. | 300.190 | 6.836 | 31/12/2023 |
| 0,54 % | JPMorgan Asset Management U.K. Limited | 293.436 | 0 | 31/12/2023 |
| 0,51 % | Northern Trust Investments, Inc. | 275.733 | 10.803 | 31/12/2023 |
| 0,48 % | Fiduciary Trust Company | 259.397 | 0 | 31/12/2023 |
| 0,40 % | Kestra Advisory Services, LLC | 216.081 | 89.598 | 31/12/2023 |
| 0,35 % | Erste Asset Management GmbH | 188.900 | 0 | 31/12/2023 |
| 0,34 % | Tepper (Robert I) | 186.423 | 149.722 | 31/12/2023 |
| 0,34 % | Adar1 Capital Management LLC | 185.894 | 185.894 | 31/12/2023 |
| 0,34 % | Renaissance Technologies LLC | 183.100 | -220.500 | 31/12/2023 |
| 0,33 % | Bridgeway Capital Management, LLC | 180.796 | 180.796 | 31/12/2023 |
| 0,33 % | Advantage Alpha Capital Partners LP | 176.871 | 176.871 | 31/12/2023 |
| 0,25 % | TD Asset Management Inc. | 133.502 | 0 | 31/12/2023 |
| 0,24 % | Bellecapital Partners AG | 130.580 | 0 | 30/9/2023 |
| 0,23 % | Sandrock Alfred W Jr | 124.470 | -12.115 | 2/4/2024 |
| 0,22 % | Rafferty Asset Management LLC | 119.216 | 119.216 | 31/3/2024 |
| 0,21 % | Swartz (Robin) | 111.720 | -1.357 | 2/4/2024 |
| 0,20 % | MFS Investment Management | 110.926 | -3.505 | 31/12/2023 |
| 0,20 % | Goldman Sachs Asset Management, L.P. | 106.808 | 9.284 | 31/12/2023 |
| 0,19 % | BNY Mellon Asset Management | 106.022 | -1.610 | 31/12/2023 |
| 0,19 % | Ferguson (Toby) | 105.000 | 105.000 | 1/4/2024 |
| 0,18 % | ARIAD Asset Management GmbH | 100.000 | -16.800 | 31/1/2024 |
| 0,18 % | Allspring Global Investments, LLC | 99.306 | 2.030 | 31/3/2024 |
| 0,18 % | AXA Investment Managers UK Ltd. | 99.000 | 0 | 31/12/2023 |
| 0,17 % | Inspire Investing | 95.002 | 12.346 | 31/12/2023 |
| 0,17 % | Fahey (Sandell Jacquelyn) | 92.000 | 31.000 | 9/2/2024 |
| 0,17 % | Parametric Portfolio Associates LLC | 90.277 | -90.514 | 31/12/2023 |
| 0,17 % | Mellon Investments Corporation | 90.075 | 61.648 | 31/12/2023 |
| 0,16 % | Nuveen LLC | 88.425 | 0 | 31/12/2023 |
| 0,16 % | Carter (Todd Alfred) | 87.627 | 34.533 | 21/2/2024 |
| 0,16 % | First Trust Advisors L.P. | 85.839 | 2.219 | 31/12/2023 |
| 0,16 % | Charles Schwab Investment Management, Inc. | 84.737 | -3.436 | 31/12/2023 |
| 0,15 % | BlackRock Investment Management, LLC | 84.099 | -71 | 31/12/2023 |
| 0,15 % | Aviva Investors Global Services Limited | 82.783 | -4.086 | 31/12/2023 |
| 0,15 % | Morgan Stanley & Co. LLC | 82.421 | 41.612 | 31/12/2023 |
| 0,14 % | Manulife Investment Management (North America) Limited | 78.276 | 0 | 31/12/2023 |
| 0,14 % | Geraghty (James A.) | 76.588 | 0 | 10/4/2023 |
| 0,14 % | SummerHaven Investment Management, LLC | 75.372 | 1.226 | 31/3/2024 |
| 0,14 % | Marshall Wace LLP | 74.743 | -133.819 | 31/12/2023 |
| 0,13 % | Goldman Sachs & Company, Inc. | 73.217 | 29.622 | 31/12/2023 |
| 0,13 % | Hesslein Robert W | 71.772 | 25.826 | 10/4/2023 |
| 0,13 % | Morgan Stanley Smith Barney LLC | 69.352 | -903 | 31/12/2023 |
| 0,12 % | Boothbay Fund Management, LLC | 66.997 | 0 | 31/12/2023 |
| 0,12 % | Fidelity Management & Research Company LLC | 66.639 | -7.641 | 31/12/2023 |
| 0,12 % | Barclays Bank PLC | 66.201 | 47.892 | 31/12/2023 |
| 0,12 % | ClariVest Asset Management LLC | 62.848 | 13.548 | 31/12/2023 |
| 0,11 % | Avantis Investors | 59.067 | 20.724 | 31/3/2024 |
| 0,10 % | Newton Investment Management North America, LLC | 56.810 | 0 | 31/12/2023 |
| 0,10 % | DWS Investment GmbH | 53.700 | 0 | 31/12/2023 |
| 0,10 % | Putnam Investment Management, L.L.C. | 53.067 | -22.500 | 31/12/2023 |
| 0,10 % | Hussman Strategic Advisors, Inc. | 52.500 | 0 | 31/12/2023 |
| 0,09 % | The Blackstone Group | 50.848 | 0 | 31/12/2023 |
| 0,09 % | Susquehanna International Group, LLP | 47.159 | -2.988 | 31/12/2023 |
| 0,08 % | Winton Capital Management Ltd. | 45.532 | -4.094 | 31/12/2023 |
| 0,08 % | Dimensional Fund Advisors, Ltd. | 44.223 | 1.189 | 31/1/2024 |
| 0,08 % | Rhumbline Advisers Ltd. Partnership | 42.736 | -304 | 31/12/2023 |
| 0,07 % | Vestcor Inc | 38.128 | 0 | 31/12/2023 |
| 0,07 % | Two Sigma Investments, LP | 37.400 | -18.500 | 31/12/2023 |
| 0,07 % | ETF Architect | 36.496 | 36.496 | 31/12/2023 |
| 0,07 % | Alps Advisors, Inc. | 35.436 | -2.464 | 31/12/2023 |
| 0,06 % | Qube Research & Technologies Ltd | 34.163 | -63.920 | 31/12/2023 |
| 0,06 % | UBS Financial Services, Inc. | 32.694 | 18.535 | 31/12/2023 |
| 0,06 % | Northern Trust Global Investments | 31.948 | -5.893 | 31/12/2023 |
| 0,06 % | Higgins Michael | 31.314 | 31.314 | 10/4/2023 |
| 0,05 % | Raymond James Financial Services Advisors, Inc. | 28.802 | -1.775 | 31/12/2023 |
| 0,05 % | BlackRock Advisors (UK) Limited | 28.618 | 1.380 | 31/3/2024 |
| 0,05 % | T. Rowe Price International Ltd | 28.501 | 470 | 31/12/2023 |
| 0,05 % | O'Shaughnessy Asset Management, LLC | 27.865 | -23.825 | 31/12/2023 |
| 0,05 % | State of Wyoming | 26.591 | 6.077 | 31/12/2023 |
| 0,05 % | CAPTRUST Financial Advisors | 25.151 | 3.151 | 31/12/2023 |
| 0,05 % | XTX Markets LLC | 24.515 | 24.515 | 31/12/2023 |
| 0,04 % | CornerCap Investment Counsel, Inc. | 23.217 | 23.217 | 31/12/2023 |
| 0,04 % | Aevitas Wealth Management, Inc. | 22.000 | 0 | 31/12/2022 |
| 0,04 % | AllianceBernstein L.P. | 21.930 | 0 | 31/12/2023 |
| 0,04 % | Pierce (Glenn F) | 21.788 | 16.788 | 10/4/2023 |
| 0,04 % | BlackRock Asset Management Ireland Limited | 21.617 | 21.617 | 31/12/2023 |
| 0,04 % | JPMorgan Private Bank (United States) | 21.555 | 21.555 | 31/12/2023 |
| 0,04 % | Entrypoint Capital LLC | 20.723 | 20.723 | 31/12/2023 |
| 0,04 % | Ritholtz Wealth Management LLC | 19.759 | 2.089 | 31/12/2023 |
| 0,03 % | State Teachers Retirement System of Ohio | 18.600 | 0 | 31/12/2023 |
| 0,03 % | Assenagon Asset Management S.A. | 17.960 | -16.199 | 31/12/2023 |
| 0,03 % | Mirae Asset Global Investments (USA) LLC | 16.910 | 1.098 | 31/12/2023 |
| 0,03 % | MetLife Investment Management, LLC | 16.821 | 0 | 31/12/2023 |
| 0,03 % | BNP Paribas Securities Corp. North America | 16.332 | -3.750 | 31/12/2023 |
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